Relevance of Vascular Function Markers: Study on the Effects of Quercetin and Epicatechin on Blood Pressure and Vascular Function in (Pre)Hypertensive Subjects

Relevance of Vascular Function Markers: Study on the Effects of Quercetin and Epicatechin on Blood Pressure and Vascular Function in (Pre)Hypertensive Subjects - The FLAVO-studie

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39481

Enrollment

Registered

2012-08-30

Start date

2012-10-15

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High blood pressure vascular function

Interventions

During an intervention period, participants will be asked to consume capsules containing either flavonoid supplements or placebo capsules (two capsules per day). Participants will be asked to consum

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Systolic Blood Pressure between 125 and 159 mmHg • Age between 30 and 80 years • BMI > 20 and

Exclusion criteria

Exclusion criteria: • Hisory of CVD • Diabetes • Usage of cholesterol-lowering medication • Usage of non-steroidal anti-inflammatory drugs (acetylsalicylic acid, ibuprofen, naproxen) and not able or willing to stop taking them from at least 4 weeks prior to the study • Smokers • Weight loss or weight gain of 5 kg or more during the last 2 months

Design outcomes

Primary

Measure	Time frame
The primary outcome is the change in Flow-Mediated Dilation (FMD) as a marker of vascular function.	—

Secondary

Measure	Time frame
Secondary outcomes include: - Blood Pressure - Pulse-Wave Velocity - Pulse Wave Analysis - Vasomotion - Biomarkers of vascular and endothelial function - Biomarkers of inflammation - Glucose resistance (HOMA-IR)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)