Structural and functional connectivity in child psychiatric disorders

Structural and functional connectivity in child psychiatric disorders - Connectivity in Child Psychiatric disorders

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39463

Enrollment

600

Registered

2011-09-02

Start date

2011-10-17

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD attention deficit hyperactivity disorder Autism autism spectrum disorder

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: General inclusion criteria for all subject groups • Aged 6 through 18 years at initial inclusion • Ability to speak and comprehend Dutch (both participant and parent).;Inclusion criteria for subjects with autism • DSM-IV (APA, 1994) diagnosis of autism, supported by ADI-R interview;Inclusion criteria for subjects with ADHD • DSM-IV (APA, 1994) diagnosis of ADHD, supported by DISC interview ;Inclusion criteria for control subjects • No DSM-IV (APA, 1994) diagnosis, supported by DISC interview • No history of psychiatric illness in first degree family members of the subjects

Exclusion criteria

Exclusion criteria: 1) Mental retardation (IQ

Design outcomes

Primary

Measure	Time frame
The primary endpoints of this study are developmental changes in structural and functional brain connectivity. The measures of interest are resting-state functional connectivity, as assessed with resting-state functional Magnetic Resonance Imaging (rs-fMRI), myelination as assessed with Magnetization Transfer Imaging (MTI), and white matter integrity, as assessed with track-based Diffusion Tensor Imaging (DTI)-measures.	—

Measure

Time frame

The primary endpoints of this study are developmental changes in structural and functional brain connectivity. The measures of interest are resting-state functional connectivity, as assessed with resting-state functional Magnetic Resonance Imaging (rs-fMRI), myelination as assessed with Magnetization Transfer Imaging (MTI), and white matter integrity, as assessed with track-based Diffusion Tensor Imaging (DTI)-measures.

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Secondary

Measure	Time frame
An exploratory analysis of the effect of genotype on shared risk genes for autism and ADHD will be conducted and symptoms of ADHD and ASD from symptom rating scales and performance on computerized tasks will be analyzed	—

Countries

Netherlands

Outcome results