anxiety depression post-traumatic stress disorder) stress-related disorders (i.e.
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Trauma-related patients: participants meet criteria for stress-related psychopathology on the MINI-international neuropsychiatric interview (MINI), , and were exposed to multiple traumatic events according to scores on the Police Life Events Schedule (PLES) Resilient group: Participants must have experienced multiple traumatic events according to the PLES and no history of psychopathologies according to the MINI Control group: Participants must be clear from any current psychopathologies according to the MINI and have none to low exposure to traumatic events according to the PLES Inclusion criteria for all participants in general: Absence of a history of neurological disorder/disease and an absence of counter-indications to MRI. All participants will be right-handed native Dutch speakers with normal vision or contact lenses.
Exclusion criteria
Exclusion criteria: Potential participants will be screened for contraindications for fMRI, which include metal implants, heart arrhythmia, claustrophobia, and possible pregnancy. They will additionally be screened for head trauma, history of neurological or psychiatric illness and/or use of psychotropic medications. Finally, handedness will be assessed using the handedness scale. Predominantly Left-handed individuals will be excluded from the study because some left-handers have substantially different brain organization relative to right-handers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the differences in the brain activation patterns, brain structure, hormone response and genetic makeup between resilient individuals, vulnerable individuals and healthy controls. | — |
Countries
Netherlands
Outcome results
None listed