lacunar infarct silent lesions
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - First lacunar infarct, diagnosed clinically as well as radiologically. - Age of 18 years and older.
Exclusion criteria
Exclusion criteria: - Brain infarct or other cerebral pathology in recent history. - Potential source of cardio-embolism or carotic stenosis (large vessel disease) - Severe comorbidity (specified as not being able to perform Activities of Daily Living (ADL independently)), including dementia. - Limited life-expectancy - History of inflammatory disease - Contra indications for MRI o Heart valve prosthesis o Pacemaker o Intracerebral clips (aneurysm) o Intra-ocular metal pieces o Cochlear implant o Claustrophobia - When the patient does not appreciate to receive the results of the study, in particular if abnormalities are found during MRI or neuropsychological assessment, which are of great importance for the patients health.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function based on several (neuro)psychological domains: information processing speed, attention/concentration, executive functioning, memory and language. Raw test scores will be used for analyses. Presence/ progression WMLs. | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain Microbleeds. Other cerebral abnormalities observed by MRI: atrophy and other cerebral abnormalities. | — |
Countries
Netherlands
Outcome results
None listed