Attenuating social anxiety: The effect of oxytocin on (inter-)personal space, mimicry, and communication

Attenuating social anxiety: The effect of oxytocin on (inter-)personal space, mimicry, and communication - OXY & (I)PS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39435

Enrollment

Registered

2011-12-12

Start date

2013-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

social anxiety n/a

Interventions

per session: 24 intranasal units (IU) of oxytocin, administered twice within each of the two experimental sessions via a nasal spray containing 2 IU oxytocin per spray. Two times 12 sprays of oxytoc

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18-30 years old, female, good physical and mental health

Exclusion criteria

Exclusion criteria: - Pregnancy - Breast-feeding - Hormonal anticonceptives - History of medication within 1 month prior to the start of the treatment with trial medication with exception of occasional use of paracetamol - Febrile illness within 3 days before the first dose. - Participation in another drug study within 3 months preceding participation in the current study. - Inability to understand the nature and extent of the trial and the procedures required.

Design outcomes

Primary

Measure	Time frame
Main outcome-measures consist of the results of the test battery measurements including trait questionnaires such as the Liebowitz, Social Anxiety Scale (LSAS; Liebowitz, 1987), the Fear of Positive Evaluation Scale (FPE; Weeks, Heimberg, & Rodebaugh, 2008), the Social Interaction Anxiety Scale (SIAS; Mattick, & Clarke, 1998),the Center of Epidemiologic Studies Depression Scale (CES-D; Ratloff, 1977), the trait versie van de Spielberger State/Trait Anxiety Scale (Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983), the UCLA Loneliness Scale (Russell, 1996), the partner questionnaire (Newman-Norlund, et al., 2009), the Need for Cognition Scale (NCS, Cacioppo, 1996), the Empathy Quotient (EQ, Baron-Cohen & Wheelswright, 2004)/Systemizing Quotient (SQ-R, Wheelswright, et al., 2006), the Interpersonal Reactivity Index (IRI, Davis, 1983), the Inclusion of Other in the Self Scale (Aron, Aron, & Smollan, 1992) and various self-constructed Visual Analogue Scales (VAS). In addition, testsosterone/cortisol, will be assessed via salivary sampling, and the 'second-to-fourth-digit' ratio of the dominant hand will be measured. This will help to control for hormones that are suspected to influence social behaviors. The test battery consists of five different paradigms: (1) an IVE task measuring interpersonal distance (2) an IVE task measuring mimicry and (3) a task assessing personal space, a (4) task measuring freeze-behavior and a (5) task that assesses non-verbal communication behavior. These tasks measure behaviors related to social interaction from different angles and aim to reflect everyday social encounters more validly.	—

Measure

Time frame

Main outcome-measures consist of the results of the test battery measurements including trait questionnaires such as the Liebowitz, Social Anxiety Scale (LSAS; Liebowitz, 1987), the Fear of Positive Evaluation Scale (FPE; Weeks, Heimberg, & Rodebaugh, 2008), the Social Interaction Anxiety Scale (SIAS; Mattick, & Clarke, 1998),the Center of Epidemiologic Studies Depression Scale (CES-D; Ratloff, 1977), the trait versie van de Spielberger State/Trait Anxiety Scale (Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983), the UCLA Loneliness Scale (Russell, 1996), the partner questionnaire (Newman-Norlund, et al., 2009), the Need for Cognition Scale (NCS, Cacioppo, 1996), the Empathy Quotient (EQ, Baron-Cohen & Wheelswright, 2004)/Systemizing Quotient (SQ-R, Wheelswright, et al., 2006), the Interpersonal Reactivity Index (IRI, Davis, 1983), the Inclusion of Other in the Self Scale (Aron, Aron, & Smollan, 1992) and various self-constructed Visual Analogue Scales (VAS). In addition, testsosterone/cortisol, will be assessed via salivary sampling, and the 'second-to-fourth-digit' ratio of the dominant hand will be measured. This will help to control for hormones that are suspected to influence social behaviors. The test battery consists of five different paradigms: (1) an IVE task measuring interpersonal distance (2) an IVE task measuring mimicry and (3) a task assessing personal space, a (4) task measuring freeze-behavior and a (5) task that assesses non-verbal communication behavior. These tasks measure behaviors related to social interaction from different angles and aim to reflect everyday social encounters more validly.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)