Immunological factors of pain and infection in patients with burns

Immunological factors of pain and infection in patients with burns - Pain and infection in burns

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39434

Enrollment

Registered

2011-07-25

Start date

2011-06-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infectie en pijn bij brandwonden Pain and infection in burns

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: >= 5% total burned surface area Able to understand research information and able to give informed consent

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Main objectives are to analyse cytokines (IL-6, IL-10, TNFalpha), cortisol, chemokines and MBL in residual blood samples. Levels of cytokines and cortisol will be correlated with self-reported pain and psychological problems (peri-traumatic reaction to accident, depression, and anxiety) and controlled for infection. MBL levels and genotypes will be examined in relation to bacterial presence and wound healing. Levels of cytokines in eschar will examined and correlated to pain scores.	—

Measure

Time frame

Main objectives are to analyse cytokines (IL-6, IL-10, TNFalpha), cortisol, chemokines and MBL in residual blood samples. Levels of cytokines and cortisol will be correlated with self-reported pain and psychological problems (peri-traumatic reaction to accident, depression, and anxiety) and controlled for infection. MBL levels and genotypes will be examined in relation to bacterial presence and wound healing. Levels of cytokines in eschar will examined and correlated to pain scores.

—

Secondary

Measure	Time frame
We want to explore a possible relationship between cortisol on day 1 and the subjective peri-traumatic reaction to the burn event.	—

Countries

Netherlands

Outcome results