Prader-Willi Syndrome
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Children and adolescents with genetically confirmed PWS and known genetic defect between 6-25 years old and healthy age- and sex-matched controls Written Informed consent of the caregivers and children and adolescents older than 12 years and assent of patients/children younger than 12 years Written informed consent of healthy adult controls Successful completion of the mock MRI scanner protocol for healthy controls under 12 years old
Exclusion criteria
Exclusion criteria: Other chromosomal abnormalities Claustrophobia Contra-indications for MRI scanner The use of medication for treating anxiety, mood disorders or psychiatric disturbances including the regular use of homeopathic St John*s wort preparations for longer than two weeks Expected or proven non-compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will measure multiple parameters such as total brain volume, grey matter/white matter volume, volumes of various brain structures (such as pituitary gland, caudate nucleus, hippocampus, hypothalamus), white matter connections (corpus callosum, anterior and posterior commisures), connectivity within the different lobes. We will further investigate the known functional networks within the brain by means of resting state fMRI. Longitudinal changes in structure and function will be assessed as well. | — |
Countries
Netherlands
Outcome results
None listed