The impact of cytotoxic T lymphocytes on the lifespan of productively infected cells in HIV infection

The impact of cytotoxic T lymphocytes on the lifespan of productively infected cells in HIV infection - THILIHT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39416

Enrollment

Registered

2011-01-31

Start date

2011-04-08

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AIDS HIV

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Written informed consent, including permission to store blood samples. 2. 18 years or older. 3. Diagnosis of HIV-1 infection: detectable plasma HIV-1 RNA load and/or serum p24 antigen 4. Infection with subtype B HIV-1 5. No prior antiretroviral treatment 6. Patient is scheduled to start the first HAART 7. A regimen including efavirenz or rilpivirine next to a backbone of two nucleot(s)ide reverse transcriptase inhibitors is to be administered

Exclusion criteria

Exclusion criteria: 1. CD4 count

Design outcomes

Primary

Measure	Time frame
Primarily we will determine the average lifespan and dynamics of (productively) infected cells in different individuals and correlate this with parameters of the CTL-response (the height, breadth and quality of the T-cell response against HIV-gag epitopes) before HAART and/or the HLA background of the subjects.	—

Secondary

Measure	Time frame
NVT	—

Countries

Netherlands

Outcome results