Brain networks involved in essential tremor: elucidating tremor pathophysiology using EMG-fMRI

Brain networks involved in essential tremor: elucidating tremor pathophysiology using EMG-fMRI - ET brain networks

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39415

Enrollment

130

Registered

2011-04-28

Start date

2011-11-21

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

essential tremor trembling

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy subjects: - subjectively healthy, including vision (after correction) - 18 years or older and as well as possible age-matched with patients - informed consent - righthanded according to the Annett Handedness scale ET patients: - ET according to the cirteria defined by the Tremor Investigation Group - using propranolol or primidone effectively (determined subjectively) and willing to stop this medication temporarily, or intention to start medication use - heriditary ET - informed consent - 18 years or older - righthanded acoording to the Annett Handedness scale - subjectively healthy (except for tremor), including vision (after correction)

Exclusion criteria

Exclusion criteria: ET patients: - absent (Tremor Rating Scale (TRS) Part A 2 UE

Design outcomes

Primary

Measure	Time frame
Main outcome measures: changes in patterns of BOLD-signal, coupled to changes in tremor intensity, extent of differentiated muscl use, and kinematic parameters such as reaction time, velocity and acceleration and the presence of 'overshoot'. The different patient groups will be compared to each other and to a healthy control group.	—

Countries

Netherlands

Outcome results