Prospective comparison of cardiac PET/CT, SPECT/CT perfusion imaging and CT coronary angiography with invasive coronary angiography

Prospective comparison of cardiac PET/CT, SPECT/CT perfusion imaging and CT coronary angiography with invasive coronary angiography - The PACIFIC-trail

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39411

Enrollment

210

Registered

2012-01-03

Start date

2012-01-02

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

'coronary artery disease' atherosclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Presenting with chest pain to the cardiologist. - Previous myocardial infarction - Presenting for a clinically referred invasive coronary angiography - Age above 40 years

Exclusion criteria

Exclusion criteria: - History of severe COPD or chronic asthma - Pregnancy - Renal failure ( i.e. eGFR

Design outcomes

Primary

Measure	Time frame
quantitative myocardial blood flow values obtained with PET/CT imaging. Quantitative myocardial perfusion images obtained with SPECT/CT. Quantification of the myocardial infarct size using MRI. Coronary artery stenosis severity obtained with invasive coronary angiography Fractional Flow Reserve values obtained during invasive coronary angiography Intracoronary Doppler Flow measurements Assessment of myocardial perfusion using thermodilution Sensitivity, specificity, positive and negative predictive value will be calculated. In additional, a combined analyses of both PET/CT and CTCA as well as SPECT/CT and CTCA results will be performed to evaluate the surplus value of combined imaging.	—

Measure

Time frame

quantitative myocardial blood flow values obtained with PET/CT imaging. Quantitative myocardial perfusion images obtained with SPECT/CT. Quantification of the myocardial infarct size using MRI. Coronary artery stenosis severity obtained with invasive coronary angiography Fractional Flow Reserve values obtained during invasive coronary angiography Intracoronary Doppler Flow measurements Assessment of myocardial perfusion using thermodilution Sensitivity, specificity, positive and negative predictive value will be calculated. In additional, a combined analyses of both PET/CT and CTCA as well as SPECT/CT and CTCA results will be performed to evaluate the surplus value of combined imaging.

—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results