atherosclerosis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with cerebrovascular symptoms (TIA, minor stroke) in the last six months. - CTA of the carotid arteries at the Erasmus Medical Center during the last 2 months (CTA is performed for clinical work-up). - Scheduled endarterectomy of a carotid artery - Signed informed consent - At least 50 years old - Patients who have a documented allergy to MRI contrast media are eligible for MRI, but will not undergo a contrast-enhanced scan. - Patients with a renal clearance (eGFR)
Exclusion criteria
Exclusion criteria: - Woman who are pregnant or lactating. - Patients who are hemodynamically unstable. - Having any physical or mental status that interferes with the informed consent procedure. - Not being able to remain lying down for at least 40-45 min (e.g. patients with unstable angina, dyspnea at rest, severe pain at rest, severe back pain) - Contraindications for MRI (e.g. claustrophobia, pacemaker,*)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - MRI Plaque quantification by basic morphological parameters (Plaque burden, Lumen, Outer wall area) and plaque composition (Fibrous cap, ulcerations, lipid rich necrotic core (LC/NR), calcifications, intraplaque hemorrhage) - Histology from the removed atherosclerotic plaque | — |
Countries
Netherlands
Outcome results
None listed