MRI and neuropsychological evaluation in systemic sclerosis

MRI and neuropsychological evaluation in systemic sclerosis - MRI and neuropsychological evaluation in systemic sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39408

Enrollment

200

Registered

2012-04-10

Start date

2012-10-19

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

scleroderma systemic sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. systemic sclerosis according to ACR criteria 2. presence of cognitive dysfunction, fatigue, concentration loss, and/or depression

Exclusion criteria

Exclusion criteria: 1. Routine MRI-contraindications (e.g. instable metal implants, pacemaker/ICD, vascular clips, fear). 2. Pregnancy

Design outcomes

Primary

Measure	Time frame
The following questionnaires: Fatigue Indez (MVI-20) the Hospital Anxiety and Depression Scale (HADS) the Dissociation Experience Scale (DES), and the Neuropsychiatric Inventory (NPI). The following functional neuropsychology tests are performed at the department of Neurology: a) global functioning (assessed by Mini mental state examination (MMSE), b) memory (Wechsler Memory scale), c) executive testing (Trails, Stroop, Wais-R substitution, number strike through test, d) language: (Word Fluency, naming pictures, writing and calculating) e) praxis (drawing a clock, map and cube). The following neuroimaging parameters: 1)Diffusion Weighted Imaging (DWI) 2)Single Voxel Proton Magnetic Resonance Spectroscopy (H1-MRS)	—

Measure

Time frame

The following questionnaires: Fatigue Indez (MVI-20) the Hospital Anxiety and Depression Scale (HADS) the Dissociation Experience Scale (DES), and the Neuropsychiatric Inventory (NPI). The following functional neuropsychology tests are performed at the department of Neurology: a) global functioning (assessed by Mini mental state examination (MMSE), b) memory (Wechsler Memory scale), c) executive testing (Trails, Stroop, Wais-R substitution, number strike through test, d) language: (Word Fluency, naming pictures, writing and calculating) e) praxis (drawing a clock, map and cube). The following neuroimaging parameters: 1)Diffusion Weighted Imaging (DWI) 2)Single Voxel Proton Magnetic Resonance Spectroscopy (H1-MRS)

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Countries

Netherlands

Outcome results