sleep apnea
Conditions
Interventions
Each patient acts as his or her own control and receives 5 Pairs of treatments.
Each pair consist of one night treatment with low pressure CPAP with added dead
space(rebreathing) and a one night tre
Sponsors
Medisch Centrum Alkmaar
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: outpatients diagnosed with central sleep apnea syndrome by polysomnography with sleep apnea index *15 and at least 50% of all apneas is central in origin without obstructieve components. Age 18-80 years Patients are using or have been using CPAP. Informed Consent
Exclusion criteria
Exclusion criteria: History of heart failure, cardiac arrhythmia or cardiac ischemia, History of stroke Cheyne Stokes breathing during daytime, Sedatives or hypnotic agents, opioids., Respiratory failure( hypoxia, hypercapnia or respiratory acidosis during daytime) Pulmonary diseases Body mass index * 30 Untreated thyroid disease pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters/endpoints Apnea Hypopnea Index with low-pressure nCPAP and added dead space versus low-pressure nCPAP only | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters/endpoints * Blood pressure measured during low-pressure nCPAP with added dead space and low-pressure nCPAP only. * Sleep structure during low-pressure nCPAP with added dead space and low-pressure nCPAP only. * Subjective quality of sleep during low-pressure nCPAP with added dead space and low-pressure nCPAP only. * Heartrate variability during low-pressure nCPAP with added dead space and low-pressure nCPAP only. | — |
Countries
Netherlands
Outcome results
None listed