gestational hypertension toxicosis
Conditions
Interventions
Temporising of pregnancy starting 24 hours after randomisation. Pregnancy will
only be terminated when maternal and/or fetal complications occur or when the
gestational age of 34 weeks is reached.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Informed consent Working knowledge of Dutch language Gestational age 27.6 - 33.5 weeks at inclusion Estimated fetal weight >= 500 gram at inclusion No major fetal congenital anomalies Severe preeclampsia (modified from the criteria for severe preeclampsia (ACOG practice bulletin no. 33, table 1))
Exclusion criteria
Exclusion criteria: Therapy resistant hypertension Severe maternal complications Fetal indication for immediate delivery Major fetal congenital anomalies or estimated fetal weight below 500 grams
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is composite major neonatal morbidity and perinatal mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary long-term neonatal outcome is a Bailey assessment at two years corrected age. The secondary short-term maternal outcome is the occurrence of major complications before and after delivery. The secondary long-term maternal outcome is persistent morbidity or death. Cost analysis calculates direct health care costs of mother and infant until discharge. | — |
Countries
Netherlands
Outcome results
None listed