20 gezonde proefpersonen tbv extra onderzoek beweegedrag fatigue multiple sclerosis
Conditions
Interventions
1) Aerobic Training consists of 12 individual therapist-supervised 45-minute
physical exercise sessions with an intensity of at least 60%VO2max in a period
of 4 months
[10] in the first 8 weeks one therapist-supervised session will be
given per week, in the subsequent 8 weeks one therapist-supervised session will
be given every other week. The sessions include a w
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of MS according to the criteria of McDonald - an Expanded Disability Status Scale score of 6 or lower, i.e. able to walk without walking aid, - suffering from fatigue, defined as a score higher than 35 on the subscale fatigue of the Checklist Individual Strength (CIS) - In the last three months prior to inclusion the patients should not have used Amantadine, Modafinil, Ritalin or Pemoline for their fatigue. - Age between 18-70 years
Exclusion criteria
Exclusion criteria: Treatable causes of fatigue. other than central MS-related fatigue
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue: Checklist Individual Strength (CIS) subscale fatigue Participation: Impact on Participation and Autonomy (IPA) Disease Activity: Number of exacerbations | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary outcome parameters: QoL: Medical Outcome study Short Form 36 (SF36) Rehabilitation Activities Profile (RAP) Fatigue Severity Scale (FSS) Patient-related variables: Socio-demographic (age, gender, ethnicity, living arrangement, employment, SES, etc) Diagnosis MS Severity of MS: Expanded Disability Status Scale Severity of fatigue: Checklist Individual Strength (CIS) subscale fatigue Comorbidities: Cumulative Illness Rating Scale (CIRS) Diagnosis of treatable causes fatigue Fatigue Medication | — |
Countries
Netherlands
Outcome results
None listed