hypertensie high blood pressure hypertension
Conditions
Interventions
Patients will be symmetrically randomized to a liberal sodium diet aimed at 150
mmol (9 grams) daily (control group) or a low sodium diet aimed at 50 mmol (3
grams) daily (intervention group) for 6
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Written informed consent - Male and female renal transplant recipients - Transplantation performed in the UMCG/AMC - Patients that are one year after transplantation or beyond - 18 years or older - Stable renal function at study entry - Use of RAAS-blockade: either an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB)
Exclusion criteria
Exclusion criteria: - Blood pressure 160/95 mmHg - Complaints or signs of orthostatic hypotension - Creatinine clearance 1.5 g/24h - Severe general diseases or mental disorders making the participation in the study impossible - Pregnancy - Being on a cyclosporine withdrawal regimen - Rejection of the allograft for which a switch in immunosuppressive medication is necessary - Drug abuse - No sufficient knowledge of the Dutch language to participate in the study - Participation in an other intervention study during or within a month prior to this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Blood pressure -and use of antihypertensive medication | — |
Secondary
| Measure | Time frame |
|---|---|
| - Plasma NT-proBNP - Relative changes between low and liberal sodium intake in stroke volume, cardiac output and SVR and baroreflex sensitivity as measured by NexfinTM (in the AMC) both supine and after 5 minutes standing - Urinary protein and albumin excretion - Urinary excretion of tubulo-interstitial damage markers (e.g. KIM-1, NAG, NGAL, AAP, TGFB, CTFG) | — |
Countries
Netherlands
Outcome results
None listed