The role of genetic factors in the aetiology of achalasia

The role of genetic factors in the aetiology of achalasia - Genetics in achalasia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39386

Enrollment

450

Registered

2012-08-27

Start date

2012-08-31

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Achalasia Oesophageal motility disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Diagnosis of idiopathic achalasia confirmed by oesophageal manometry that show the following criteria: - Aperistalsis or simultaneous contractions in the oesophageal body. - LOS dysrelaxation. - Age *18 years. - Written informed consent.

Exclusion criteria

Exclusion criteria: - Having a medical or mental contradictory condition to participate in the study, even after agreeing to participate. - Pseudoachalasia. - Upper gastrointestinal malignancy. - Chagas disease. - Previous allogeneic bone marrow transplant. - Non leukocyte depleted whole blood transfusion within 120 days of the date of genetic sample collection.

Design outcomes

Primary

Measure	Time frame
Genetic variants associated with achalasia.	—

Secondary

Measure	Time frame
Demographic and clinical data on idiopathic achalasia.	—

Countries

Netherlands

Outcome results