Effect of a standard oral salt loading test on the renin-angiotensin-aldosterone system in healthy subjects - assessment of reference values

Effect of a standard oral salt loading test on the renin-angiotensin-aldosterone system in healthy subjects - assessment of reference values - RAAS changes after salt loading

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39385

Enrollment

100

Registered

2006-10-05

Start date

2006-11-22

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adrenal hypertension primary aldosteronism

Interventions

All participants will be exposed to a standard oral salt loading test.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy male and female subjects with a normal blood pressure (RR

Exclusion criteria

Exclusion criteria: - hypertension (RR>140/90mmHg) - past medical history of heart failure - elevated liver enzymes (ALAT, ASAT, gGT, AF > 1.5 URL) - renal insufficiency (serum creatinine > 110 micrmol/l) - diabetes mellitus (any type) - pregnancy - use of specific drugs: antihypertensives, nonsteroidal anti-inflammatory drugs, diuretics, potassium supplements

Design outcomes

Primary

Measure	Time frame
Changes in renin-angiotensin-aldosterone system (RAAS) after an oral salt loading test. The following RAAS parameters will be measured: plasma renin concentration, plasma renin activity, serum aldosterone, urinary aldosterone (free + metabolites)	—

Secondary

Measure	Time frame
Influence of OC's on previously described RAAS parameters before and after salt loading.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)