fibrosing interstitial lung disease lung fibrosis
Conditions
Interventions
None listed
Sponsors
Onze Lieve Vrouwe Gasthuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -IIP patients, defined as IPF or fibrotic NSIP will be included in the study. Diagnosis ill be made according to the ATS/ERS guidelines (1, 23). - Informed consent - > 18 years of age - Male and female
Exclusion criteria
Exclusion criteria: -Occupational or environmental cause for the pulmonary fibrosis. -Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are systolic pulmonary arterial pressure and ventilatory equivalents for CO2 at anaerobic threshold | — |
Secondary
| Measure | Time frame |
|---|---|
| CPET parameters; peak oxygen uptake (peak V*O2), V*O2 at the anaerobic threshold, ventilatory reserve, the ventilatory equivalent for O2 and CO2 (V*E/ V*O2 and V*E/V*CO2) at peak exercise, and oxygen-pulse (O2-pulse (V*O2/HR)). Baseline spirometry and diffusion capacity. Biomarkers of (left and right) ventricular strain (NT-proBNP). | — |
Countries
Netherlands
Outcome results
None listed