atherosclerotic plaque hardening of the arteries
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with a carotid artery stenosis, who are scheduled for carotid endarterectomy - age 18 years or older (no maximum age) - informed consent by signing informed consent form regarding this study - inclusion criteria carotid endarterectomy: * symptomatic carotid artery stenosis 70-99% within 3 months of neurologic symptoms * symptomatic carotid artery stenosis 50-99% in man within 2 weeks of neurologic symptoms * asymptomatic carotid artery stenosis 70-99% with contralateral occlusion
Exclusion criteria
Exclusion criteria: * Severe co-morbidity, dementia or pregnancy * Standard contra-indications for MRI (ferromagnetic implants like pacemakers or other electronic implants, metallic eye fragments, vascular clips, claustrophobia, etc.) * Patients who have a documented allergy to MRI or CT contrast media * Patients with a renal clearance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - MRI: correlation between neovascularisation in carotid atherosclerotic plaque characteristics assessed by dynamic 3.0 Tesla MRI and carotid atherosclerotic plaque at histology. - CT: correlation between size of lipid-rich-necrotic-core in dual-energy CT and histology. | — |
Secondary
| Measure | Time frame |
|---|---|
| - MRI: correlation between volume of LRNC, fibrous cap status, and volume of calcifications in carotid atherosclerotic plaques visualised by MRI and carotid atherosclerotic plaques at histology. - Ultrasound: correlation between deformation pattern and plaque composition and volume of LRNC at histology. - TCD: relation between number of recorded MES and fibrous cap status. | — |
Countries
Netherlands
Outcome results
None listed