major depressive disorder melancholia
Conditions
Interventions
In the treatment arm where AD will be continued GP*s and psychiatrists will be
advised to prescribe continuation/maintenance AD as recommended by national
guidelines (2005) continuing AD at minimal
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with major depressive disorder (DSM-IV) with at least two previous depressive episodes in the past five years. Last episode was treated succesfully with an antidepressant and the patient is still using that antidepressant at an adequate dose (recommended minimum dose according to Farmacotherapeutisch Kompas. Currently in remission according to DSM-IV criteria, for at least 8 weeks and no longer than 2 years. A current score of
Exclusion criteria
Exclusion criteria: * Bipolar I of bipolar II disorder (indicated by previous or current manic or hypomanic episode (DSM-IV) * serious neurological or somatic disorder (including organic brain damage) as possible cause of depression * alcohol or drug abuse during the last six months; alcohol or drug dependence during two years * comorbid anxiety disorder, necessitating additional treatment * ongoing or recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of relapse/recurrence in a survival analysis over a follow up period of 2 years using DSM-IV criteria as assessed bij the Structural Interview for DSM-IV (SCID I) at 3, 12 and 24 months (current depressive symptomatology and previous 3 and 6 months). Assessment HDSR at screening, 3, 12 en 24 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of Episodes and severity of depression: SCID-I and Inventory of Depression Symptomatology (IDS-SR 18). Predictors and mediators: avoidance of emotions: AAQ II rumination: RRS-uitgebreide extended version Dysfunctional attitude scale (DAS-A) Attribution Style (DASQ and LEIDS) Every Day Problem Checklist (EPCL 20) Negative Life Events Questionnaire (NLEQ 21) Coping (UCL) Assess medication adherence: Medication Adherence Questionnaire (MAQ22) Economic evaluation: quality adjusted life years (EQ5D) Implicit attitudes en attentional bias Impliciete Associatie test (IAT24) Assess the difficulty to disengage from negative information: Rapid Serial Visual Presentation (RSVP) task New addition June 5 2013: Effect in daily life: PsyMate DNA-assessment: Saliva sample | — |
Countries
Netherlands
Outcome results
None listed