delayed cerebral ischemia after subarachnoid ahemorrhage: an prospective observational study

delayed cerebral ischemia after subarachnoid ahemorrhage: an prospective observational study - DISCOVER

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39377

Enrollment

100

Registered

2012-08-31

Start date

2013-02-21

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain haemorrhage stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with suspected aneurysmal subrarachnoid haemorrhage

Exclusion criteria

Exclusion criteria: 1) Under 18 years of age 2) Presentation >72 hours after initial ictus of haemorrhage 3) If death appears imminent

Design outcomes

Primary

Measure	Time frame
The relationship of delayed cerebral ischemia occurence with blood coagulation parameters and sex hormones: -ESR, Blood count, Glucose, Kreatinine, Calcium, Albumin, Magnesium, CRP -D-dimer, Von Willebrand factor, ADAMTS13, Prothrombin fragment 1 and 2, Endogenious thrombin potential -17-beta-estradiol, Progesterone, Testosterone, Dihydrotestosterone	—

Secondary

Measure	Time frame
1) To evaluate whether occurrence of DCI after SAH is gender-specific 2) To study imaging of patient with SAH in order to evaluate whether patients with and without DCI develop cerebral infarction. 3) To assess whether the glycocalyx is affected in SAH patients and is related to its severity and the development of DCI. 4) To evaluate whether glycocalyx perturbation is associated with vasomotion changes as non-invasively assessed by finger arterial waveform registration, in SAH patients.	—

Measure

Time frame

1) To evaluate whether occurrence of DCI after SAH is gender-specific 2) To study imaging of patient with SAH in order to evaluate whether patients with and without DCI develop cerebral infarction. 3) To assess whether the glycocalyx is affected in SAH patients and is related to its severity and the development of DCI. 4) To evaluate whether glycocalyx perturbation is associated with vasomotion changes as non-invasively assessed by finger arterial waveform registration, in SAH patients.

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Countries

Netherlands

Outcome results