Red wine polyphenols improve cardiometabolic risk in obese subjects by alleviating inflammation and microvascular dysfunction

Red wine polyphenols improve cardiometabolic risk in obese subjects by alleviating inflammation and microvascular dysfunction - The effects of red wine polyphenols on microvascular function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39376

Enrollment

Registered

2011-12-05

Start date

2012-05-15

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

microvascular dysfunction small vessel disease

Interventions

mixed RWP 600mg/day (Provinols*, SEPPIC-France

corresponds to polyphenol content of 6 glasses of red wine) or matching placebo for a total duration of 8 weeks

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Obese (BMI *30) Age 18-70 years Caucasian

Exclusion criteria

Exclusion criteria: cardiovascular disease diabetes mellitus recent history ( 4 U/day use of medication potentially affection insulin sensitivity or microvasculair function pregnancy smoking

Design outcomes

Primary

Measure	Time frame
insulin sensitivity will be assessed during a hyperinsulinemic-euglycemic clamp. Skeletal muscle perfusion measured by contrast-enhanced ultrasonography before and during hyperinsulinemia/meal test. skin microvascular function (capillary microscopy and laser-doppler fluxmetry with iontophoresis) trancutaneous quadriceps muscle biopsy . Using Western blotting, phosphorylation of relevant molecules in the insulin signaling cascade will be assessed.	—

Measure

Time frame

insulin sensitivity will be assessed during a hyperinsulinemic-euglycemic clamp. Skeletal muscle perfusion measured by contrast-enhanced ultrasonography before and during hyperinsulinemia/meal test. skin microvascular function (capillary microscopy and laser-doppler fluxmetry with iontophoresis) trancutaneous quadriceps muscle biopsy . Using Western blotting, phosphorylation of relevant molecules in the insulin signaling cascade will be assessed.

—

Secondary

Measure	Time frame
24-hr ambulant blood pressure measurement markers of low-grade inflammation (hsCRP, fibrinogen, IL-6, TNF-alpha) and adipocytokines (circulating whole-adiponectin, leptin).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)