increased phytosterol concentrations
Conditions
Interventions
Subjects will be asked to consume three times daily control capsules, vitamin E
capsules (total 804 mg) or lipoic acid capsules (total 600 mg) for three
periods of four weeks. They will be asked to
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 75 years Body Mass Index (BMI) between 20-35 kg/m2 Mean serum total cholesterol 7.8 mmol/l and
Exclusion criteria
Exclusion criteria: Unstable body weight (weight gain or loss > 3 kg in the past two months) Active cardiovascular diseases like congestive heart failure or recent (21 units per week) Not willing to stop the consumption of vitamin supplements, containing lipoic acid and/or vitamin E, 1 month before the start of the study (wash-in period) Use of an investigational product within another biomedical study within the previous month Pregnant or breast-feeding women Current smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples will be drawn at week 1, 3 and 4 of each test period. The samples will be analysed for serum / plasma concentrations of plant sterols and oxyphytosterols. | — |
Secondary
| Measure | Time frame |
|---|---|
| Samples will also be analysed for oxidative stress markers, antioxidant capacity, lipoproteins, and for markers reflecting low-grade systemic inflammation and endothelial dysfunction. | — |
Countries
Netherlands
Outcome results
None listed