onderzoek heeft in de toekomst betrekking op bovenstaande aandoeningen, maar wordt uitgevoerd bij gezonde controles NMDA receptor function (not a specific disease)
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Men and women; - Age between 18-40 years; - Good physical health evaluated by medical history, physical (including neurological) examination and screening laboratory tests (Haemoglobin (Hb) must be 8 mmol \ litre at the time of the screening for males and 7 mmol \ litre for females); - Weight 50 kg; - Never mentally ill according to Research Diagnostic Criteria (RDC); - A negative pregnancy test must be obtained for all females within 48 hours before starting the PET scan;- Normal MRI scan as evaluated by a neuroradiologist; - Written informed consent of the subject;
Exclusion criteria
Exclusion criteria: - (History of) Any psychiatric or neurological disorder (DSM-IV criteria); - Coronary heart disease; - (History of) Alcohol and/or drug abuse (DSM-IV criteria); - Any clinical significant abnormality of any clinical laboratory test, including drug screening; - Any condition that may interfere with MRI scanning, e.g. metal objects in or around the body or claustrophobia; - Blood donation or substantial blood loss within 3 months before the PET scan; - Intake of investigational medication within 30 days prior to the start of this study; - Pregnancy; - Smoking;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objectives: i) To examine the regional brain uptake and its metabolites of [11C]GMOM in healthy volunteers. ii) To examine the specific binding potential of [11C]GMOM in the brain in healthy volunteers before and after ketamine displacement iii) To assess the whole body biodistribution and to determine the dosimetry of [11C]GMOM in healthy volunteers. | — |
Countries
Netherlands
Outcome results
None listed