Barret's esophagus
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For the group with advanced esophageal adenocarcinoma > stage 1A : • Patients older than 18 years with esophageal adenocarinoma with stage 1B or higher that are scheduled for esophagogastroduodenoscopy. For the high-grade dysplasia or esophageal adenocarcinoma group: • Patients older than 18 years with Barrett's esophagus and esophageal adenocarinoma until stage 1A (established on the basis of a histological biopsy) that are scheduled for esophagogastroduodenoscopy. For the non-dysplastic Barrett's esophagus group: • Patients older than 18 years with long-standing non-dysplastic Barrett's esophagus that are under surveillance and have not shown any signs of malignant progression. For the gastro-esophgeal reflux disease group patients: • Patients older than 18 years without Barrett's esophagus but with reflux disease, confirmed by an esophagogastroduodenoscopy For the control group patients: • Patients older than 18 years without Barrett's esophagus or reflux disease, confirmed by an esophagogastroduodenoscopy
Exclusion criteria
Exclusion criteria: • Patients younger than 18 years • Patients unfit to undergo esophagogastroduodenoscopy. • Patients in whom no samples of either squamous epithelium, Barrett's esophagus or esophageal adenocarcinoma epithelium could be obtained for different reasons, as judged by the endoscopist • For the gastro-esophgeal reflux disease group patients: the presence of Barrett's esophagus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The patient part of the study will be finished when sufficient sample series are collected for each group of patients. After this, the study will continue without patient involvement and will consist of analyzing data from patient material. The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the development and malignant progression of Barrett's esophagus ( See research protocol p. 13). | — |
Countries
Netherlands
Outcome results
None listed