ADHD Attention Deficit Hyperactivity Disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for parents: • No additional criteria if a child meets all of the inclusion criteria;General inclusion criteria for all subject groups (excluding parents): • Aged 6 through 18 years at first scan • Ability to speak and comprehend Dutch;Inclusion criteria for subjects with ADHD • Clinical DSM-IV diagnosis of ADHD, supported by the Diagnostic Interview Schedule for Children (DISC) ;Inclusion criteria for control subjects • No DSM-IV diagnosis, according to the DISC • No scores in the clinical range on any scale of the Child Behavior Checklist (CBCL) as reported by one of the parents.;Inclusion criteria for subjects with a psychiatric diagnosis but no diagnosis of ADHD • Any clinical DSM-IV diagnosis except ADHD, supported by the DISC interview • A score in the subclinical or clinical range of the CBCL subscale of Attention Problems as reported by one of the parents.
Exclusion criteria
Exclusion criteria: Mental retardation (IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter/endpoint (1) Task related brain activity (BOLD-signal change) and connectivity measures from fMRI (2) Neuropsychological performance measures collected with computerized tasks | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters/endpoints (1) Resting-state functional connectivity, assessed with resting-state fMRI (2) Symptoms of ADHD from symptom rating scales (CBCL/TRF/SWAN) (3) White matter integrity, assessed using tract-based FA (Fractional Anisotropy) measures from DTI (Diffusion Tensor Imaging) (4) Genotype on risk genes for ADHD | — |
Countries
Netherlands
Outcome results
None listed