Onderzoek vindt plaats in gezonde ouderen en ouderen met sarcopenie age-related loss of muscle mass and muscle function Sarcopenia
Conditions
Interventions
One single-bolus of one of the three study products
Sponsors
Nutricia Danone Research - Centre for Specialised Nutrition
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 65 y or older - Male - Healthy (n = 45) or sarcopenia (n = 15) - BMI from 20 through 30 kg/m2 - Written informed consent
Exclusion criteria
Exclusion criteria: - Indications related to inadequate glycemic control - All co-morbidities interacting with mobility and/or muscle metabolism of the lower limbs - Any (history of) gastrointestinal disease that interferes with GI function - Diabetes Mellitus type I or II - Adherence to a weight loss diet - Use of protein containing or amino acid containing nutritional supplements within one week of study entry - Participation in any regular exercise program focusing on improving skeletal muscle mass - Known allergy to milk and milk products - Known galactosaemia - Blood diseases, use of anticoagulants or allergy for lidocaine, because of muscle biopsy collection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mixed muscle protein fractional synthetic rate (FSR) [%/h] | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma leucine (Leumax [umol/L]; LeuiAUC [umol/(L*min)]) Plasma essential amino acids (EAAmax [umol/L]; EAAiAUC [umol/(L*min)]) | — |
Countries
Netherlands
Outcome results
None listed