Procalcitonin to guide obtaining bloodcultures in the ICU.

Procalcitonin to guide obtaining bloodcultures in the ICU. - ProBIC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39326

Enrollment

1130

Registered

2012-06-28

Start date

2013-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bloodstream infection sepsis.

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients will need to be over the age of 18, be suffering from an assumed infection deemed clinically worthy for blood culturing.

Exclusion criteria

Exclusion criteria: - Pregnancy. - Neutropenia, defined as leukocyte count less then 0,5x10.000/L. - Moribund patients. - Predetermined illness with and expected death within 24 hours.

Design outcomes

Primary

Measure	Time frame
1. Safety, expressed as mortality at day 28 and 90, with a mortality difference not exceeding a between groups difference of 10% by non-inferiority analysis. 2. Cost-effectiveness, expressed in euro, calculated by deducting costs of procalcitonine testing from saved blood cultures compared with standard treatment spending on blood cultures in the control group.	—

Secondary

Measure	Time frame
1. Length of stay on the ICU. 2. Length of hospital stay. 3. Positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity of procalcitonin for predicting microbial bloodstream infections.	—

Countries

Netherlands

Outcome results