The value of duplex in systemic giant cell vasculitis

The value of duplex in systemic giant cell vasculitis - The value of duplex in systemic giant cell vasculitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39324

Enrollment

100

Registered

2012-07-03

Start date

2012-10-07

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

giant cell vasculitis vesselinflammation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: PET-CT proven giant cell vasuclitis

Exclusion criteria

Exclusion criteria: Legally incapable patients

Design outcomes

Primary

Measure	Time frame
The suspicion of a systemic reuscelvasculitis is based on issues such as elevated inflammatory parameters, reasonably excluding of infections, malignancy and other systemic diseases, complaints of malaise and / or fever or presence of claudication and / or ischemia. Diagnosis is made based on the gold standard nowadays: 18F-FDG PET-CT. Endpoints will include: 1. Sensitivity / Specificity of the duplex (vs. Gold standard: PET) a. In addition specifying this by specific arteries 2. Value of duplex during follow-up a Increase edema = exacerbation vasculitis? b. Decreased edema = vasculitis recovering? (and affected therapy?)	—

Measure

Time frame

The suspicion of a systemic reuscelvasculitis is based on issues such as elevated inflammatory parameters, reasonably excluding of infections, malignancy and other systemic diseases, complaints of malaise and / or fever or presence of claudication and / or ischemia. Diagnosis is made based on the gold standard nowadays: 18F-FDG PET-CT. Endpoints will include: 1. Sensitivity / Specificity of the duplex (vs. Gold standard: PET) a. In addition specifying this by specific arteries 2. Value of duplex during follow-up a Increase edema = exacerbation vasculitis? b. Decreased edema = vasculitis recovering? (and affected therapy?)

—

Secondary

Measure	Time frame
1. If the duplex shows evidence of giant cell vasculitis (halos), we will try to show at fixed intervals after initiation of treatment, how long there remain visible halos and how they change. This will be done after 4 and 8 weeks and every 8 weeks untill disappearens. Also, the duplex will be repeated when a exacerbation of the vasculitis is suspected. 2. How systemic is the vasculitis?	—

Countries

Netherlands

Outcome results