Biomarkers for differentiation of Parkinson*s disease subtypes.

Biomarkers for differentiation of Parkinson*s disease subtypes. - Biomarkers for Parkinson*s disease subtypes.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39292

Enrollment

210

Registered

2011-01-17

Start date

2012-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For all participants a minimum age of 18 years is required. All PD patients must fulfill the United Kingdom Parkinson*s Disease Society Brain Bank criteria for idiopathic PD. Patients with Lewy body dementie (DLB) must fulfill the McKeith DLB criteria and all patients must be diagnosed with PD or DLB by a movement disorder specialist. Only patients who are mental competent are included.

Exclusion criteria

Exclusion criteria: Participants with a contraindication for MRI are excluded. Patients who underwent stereotactic surgery were excluded. Controls with a disease of the central nervous system are excluded.

Design outcomes

Primary

Measure	Time frame
The main study parameters of this study will include magnetic resonance imaging (MRI) parameters, and clinical measures. Clinical data include important demographic and disease-related characteristics as well as measures for disease severity, and the important motor (motor functioning and motor complications), and non-motor domains (cognition, depression, psychotic symptoms, sleep problems, and autonomic dysfunction). The combination of clinical scores will allocate PD patients in one of the four subtypes. MRI will be carried out on a 3T scanner and will include volumetric, diffusion, and functional MRI parameters.	—

Measure

Time frame

The main study parameters of this study will include magnetic resonance imaging (MRI) parameters, and clinical measures. Clinical data include important demographic and disease-related characteristics as well as measures for disease severity, and the important motor (motor functioning and motor complications), and non-motor domains (cognition, depression, psychotic symptoms, sleep problems, and autonomic dysfunction). The combination of clinical scores will allocate PD patients in one of the four subtypes. MRI will be carried out on a 3T scanner and will include volumetric, diffusion, and functional MRI parameters.

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Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results