high blood pressure hypertension
Conditions
Interventions
group 1 takes 2 tablets of cholecalciferol 1000 IE each day for 12 months.
group 2 takes 2 placebo tablets each day for 12 months.
The placebo tablets are manufactured by the Central Hospital Pharma
Sponsors
Bronovo Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - the patient has signed an informed consent - the patient is an adult male or female (age 18 yr or above) - the patient is diagnosed with a systolic hypertension (> 140 mmHg), measured in Bronovo Hospital between t=-12 months and t=0 months - the patient is vitamin D insufficient, defined as having a 25-hydroxycholecalciferol concentration between 20-50 nmol/l measured in Bronovo Hospital between t=-12 months and t=0 months
Exclusion criteria
Exclusion criteria: - using prescribed cholecalciferol supplement (>= 400 IE/day) after t = -2 months - MDRD below normal for age/gender - for albumin corrected serum calcium > 2,60 mmol/L - existing malignancy which is treated. - disease of Besnier-Boeck (sarcoidosis) - pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| systolic blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma renin activity Aldosteron 25-hydroxycholecalciferol Alkaline phosphatase Parathyroid hormone the need of adjusting the antihypertensive therapy anti-inflammatoire activity of vitamin D | — |
Countries
Netherlands
Outcome results
None listed