Effect of mild therapeutic hypothermia in post cardiac arrest patients on inflammatory response

Effect of mild therapeutic hypothermia in post cardiac arrest patients on inflammatory response - EMIR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39281

Enrollment

Registered

2012-11-19

Start date

2013-01-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain damage cardiac arrest

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - age >=18 years - post cardiac arrest with spontaneous return of circulation - undergoing mild therapeutic hypothermia - admittance to the intensive care - written informed/deferred consent

Exclusion criteria

Exclusion criteria: -pregnancy -severe traumatic brain injury -cardiac arrest due to submersion -infection already present before collapse -moribund patients

Design outcomes

Primary

Measure	Time frame
Determine whether minor variations in the expression of systemic pro- and anti-inflammatory markers in post-CA patients during treatment with hypothermia result in better neurological outcome compared to patients showing large variations.	—

Secondary

Measure	Time frame
- Does the expression of pro- and anti-inflammatory markers relate to mechanical ventilation days, length of stay at the ICU and survival of the patients? - Is there an association between the expression of pro- and anti-inflammatory markers and speed of cooling and re-warming? - Is there an association between the expression of pro- and anti-inflammatory markers and temperature stability during the maintenance phase of MTH? - Is there a relation between hypoperfusion (measured with NIRS) and markers of inflammation before, during and after induction of MTH in post-CA patients	—

Measure

Time frame

- Does the expression of pro- and anti-inflammatory markers relate to mechanical ventilation days, length of stay at the ICU and survival of the patients? - Is there an association between the expression of pro- and anti-inflammatory markers and speed of cooling and re-warming? - Is there an association between the expression of pro- and anti-inflammatory markers and temperature stability during the maintenance phase of MTH? - Is there a relation between hypoperfusion (measured with NIRS) and markers of inflammation before, during and after induction of MTH in post-CA patients

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Countries

Netherlands

Outcome results