Exercise-induced left ventricular diastolic dysfunction in COPD patients with a symptomatic limitation to exercise

Exercise-induced left ventricular diastolic dysfunction in COPD patients with a symptomatic limitation to exercise - Left ventricular diastolic function during exercise in COPD patients.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39266

Enrollment

Registered

2013-03-27

Start date

2013-11-06

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obstructive pulmonary disease emfysema or chronic bronchitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - COPD patients classified according to the GOLD staging system and the criteria of the BODE index - Informed consent - > 18 years of age - Male and female - Patients able to perform a cycling test

Exclusion criteria

Exclusion criteria: - Age

Design outcomes

Primary

Measure	Time frame
•Exercise-induced LV-DD; defined by E/E* > 15 during stress echocardiography.	—

Secondary

Measure	Time frame
•Baseline spirometry and diffusion capacity •Inspiratory capacity, as measuer of dynamic hyperinflation •CPET parameters: peak-VO2,, VE/VCO2 and O2-pulse •Systemic inflammation: IL-18, IL-6 and hs-CRP •All other cardio-pulmonary exercise test parameters. •Sub-maximal exercise (6-MWD with Borg scores). •Daily life physical activity measured by SenseWear pro armband. •Metabolic and muscular status (BMI and Fat-free Mass). •Peripheral muscle strength measured by Jamar dynamometer. •Other markers of systemic inflammation (TNF-a, and fibrinogen, IL-8, Monocyte chemoatractant protein 1 (MCP-1)) •Markers of collagen metabolism in serum (carboxyterminal propeptide of collagen 1 (PICP), aminoterminal propeptide of collagen (PINP), amino-terminal propeptide of collagen 3 (PIIINP) and carboxy-terminal telopeptide of collagen 1 (CITP) •Matrix metalloproteinases (MMP) 2 and 9 and tissue inhibitor of MMPs in serum (TIMP1). MMP9/TIMP1 ratio as predictor of left atrial volume index. •Endothelial function measured by forearm mediated vasodilatation (FMD) •Biomarkers of (left and right) ventricular strain: NT-proBNP, troponine-T. •Other stress-induced echocardiographic parameters: sPAP and Pv-acceleration time, E/A and deceleration time, E/E*, Ard-Ad, Left atrial volume index (LAVI), left ventricular mass index (LVMI)) to determine LV-DD	—

Measure

Time frame

•Baseline spirometry and diffusion capacity •Inspiratory capacity, as measuer of dynamic hyperinflation •CPET parameters: peak-V*O2,, V*E/V*CO2 and O2-pulse •Systemic inflammation: IL-18, IL-6 and hs-CRP •All other cardio-pulmonary exercise test parameters. •Sub-maximal exercise (6-MWD with Borg scores). •Daily life physical activity measured by SenseWear pro armband. •Metabolic and muscular status (BMI and Fat-free Mass). •Peripheral muscle strength measured by Jamar dynamometer. •Other markers of systemic inflammation (TNF-a, and fibrinogen, IL-8, Monocyte chemoatractant protein 1 (MCP-1)) •Markers of collagen metabolism in serum (carboxyterminal propeptide of collagen 1 (PICP), aminoterminal propeptide of collagen (PINP), amino-terminal propeptide of collagen 3 (PIIINP) and carboxy-terminal telopeptide of collagen 1 (CITP) •Matrix metalloproteinases (MMP) 2 and 9 and tissue inhibitor of MMP*s in serum (TIMP1). MMP9/TIMP1 ratio as predictor of left atrial volume index. •Endothelial function measured by forearm mediated vasodilatation (FMD) •Biomarkers of (left and right) ventricular strain: NT-proBNP, troponine-T. •Other stress-induced echocardiographic parameters: sPAP and Pv-acceleration time, E/A and deceleration time, E/E*, Ard-Ad, Left atrial volume index (LAVI), left ventricular mass index (LVMI)) to determine LV-DD

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Countries

Netherlands

Outcome results