Amyotrophic Lateral Sclerosis muscular disease neuromuscular disease
Conditions
Interventions
The 80 patients will be randomized to one of two groups i.e. (1) aerobe
exercise therapy (AET) + usual care. AET consist of aerobic exercises for a
period of 16 weeks, 3 days a week, twice at home a
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 80 years 2. A life-expectancy longer than one year 3. Forced Vital Capacity at least 80% 4. Diagnosis of "Probable" or "definite" ALS according to the "revised El Escorial WFN criteria" 5. At least 1 month post-diagnosis ALS 6. Being in the rehabilitation phase; diagnotic phase is completed. 7. Walking-ability with or without a ankle-foot orthotic or stick and cycling-ability on a bicycle ergometer, in that capacity that the intervention is expected to be completed.
Exclusion criteria
Exclusion criteria: 1. Cognitive impairment 2. Insufficient mastery of the Dutch language 3. Disabling co-morbidity interfering with the intervention programs or influencing outcome parameters (including severe cardiopulmonair disease, like chest pain, arrhytmia, pacemaker, cardiac surgery, sever dyspnoea d'effort or emphysema, epileptic seizures, poorly regulted diabetes mellitus or hypertension. 4. Psychological disorder, in that capacity that the intervention could not be completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life (ALSAQ-40, SF-36), activities (LAPAQ, IPA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional capacity. Patients*, partners* and professionals* expectations of and experiences with the AET intervention. | — |
Countries
Netherlands
Outcome results
None listed