bipolar I disorder/ manic-depressive illness and schizophrenia
Conditions
Interventions
1 Urine sample
A urine sample will be obtained at arrival to conduct a drug test (MDMA,
barbiturates, cannabinoids, benzodiazepines, cocaine and opiates) and to test
for nicotine use.
2 Skin temper
bipolar disorder
epigenetics
genetics
schizophrenia
stress
twins
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Schizophrenia patients (n=50) 2. Bipolar I disorder patients (n=50) 3. Healthy co-twin of monozygous twins discordant for bipolar disorder (n=20) 4. Healthy volunteers groupwise matched for age, gender, smoking, alcohol use, caffeine intake and drug use (n=50) 5. Healthy siblings of bipolar I disorder patients (n=50)
Exclusion criteria
Exclusion criteria: General exclusion criteria are: - speech impairments - lack of fluency in the Dutch language - Less than 3 Dutch grand parents;Acute exclusion criteria are: - any acute illness - having a severe cold - recent physical exertion within the last 2 hours - large meal within the last 2 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hormonal stress response: stress-induced saliva cortisol | — |
Secondary
| Measure | Time frame |
|---|---|
| * Autonomic stress response o Heart rate (variability) o Body temperature o Alpha-amylase (saliva) * Immune response o Saliva o Blood * Performance on a number of cognitive tasks * Perceived Stress (questionnaires) * Genotype and genetic expression of psychiatric risk genes and genes involved in the stress system * Epigenetic DNA methylation of 27,000 loci van het genoom. | — |
Countries
Netherlands
Outcome results
None listed