Circadian timing system (CTS) characteristics in bipolar disorder: investigation of possible endophenotypes

Circadian timing system (CTS) characteristics in bipolar disorder: investigation of possible endophenotypes - Circadian rhythms in bipolar disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39203

Enrollment

600

Registered

2012-10-18

Start date

2013-04-05

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bipolar disorder manic depressive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Patients: - Bipolar I disorder according to the DSM-IV , with medical record of at least one clinical treatment for mania -Dutch ancestry -Age >18 years;Healthy controls: -Age>18 years -Dutch ancestry -IQ >80 ;Family member: - no bipolar I disorder.

Exclusion criteria

Exclusion criteria: Patients: -Age

Design outcomes

Primary

Measure	Time frame
Identifying circadian parameters as possible endophenotypes for bipolar disorder. The circadian parameters assessed in this study include rest-activity rhythm parameters (total sleep duration, sleep onset latency, sleep efficiency, interdaily stability and intradaily variability), chronotype and circadian rhythm of gene expression.	—

Secondary

Measure	Time frame
- Effects of moodstabilizers and other medication on circadian rhythm parameters. - Relationship between mood state at study entry and circadian rest-activity rhythms.	—

Countries

Netherlands

Outcome results