ETEC infection Traveler's diarrhea
Conditions
Interventions
Biopsies will be sampled from the rectum with a suction biopsy device.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Must be 18-55 years old. Enrollment by informed written consent
Exclusion criteria
Exclusion criteria: Liver conditions; signs of portal hypertension Coagulation disorders or use of anti-coagulants (Chronic) constipation. (As this may indicate aberrant intestinal ion and fluid transport.)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The effect of 6 GC-C signaling blockers on GC-C-independent intestinal solute transport, assessed by ICM (off-target effects). | — |
Primary
| Measure | Time frame |
|---|---|
| The effect of 6 GC-C signaling blockers and of 4 CFTR inhibitors on the pro-secretory response of human colon, assessed by ICM. | — |
Countries
Netherlands
Outcome results
None listed