venous thrombosis and pulmonary embolism
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient who presented with VTE in our hospital, and were also diagnosed with inherited antithrombin deficieny. (Definition: antithrombin deficiency, measured twice, and also found in at least one family member) Their family members Age >= 18 years Written informed consent
Exclusion criteria
Exclusion criteria: Not applicable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number of VTE*s, riskfactors for VTE, treatment for VTE 2. Antithrombin antigen and activity levels 3. Genetic mutations in the SERPINC1 gene | — |
Secondary
| Measure | Time frame |
|---|---|
| • To calculate the absolute and relative risk of VTE in patients with antithrombine deficiency, compared with non-deficient family members (update on previous study) • To describe current anti-coagulant therapy and history of effectiveness and safety of anti-coagulant therapy | — |
Countries
Netherlands
Outcome results
None listed