non-healing dead bone due to irradiation osteoradionecrosis radiation osteomyelitis
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients treated for cancer of the oral cavity receiving oral rehabilitation with dental implant surgery. (cases) Patients treated for oral cancer with irradiation and dental implants, complicated by osteoradionecrosis. Healthy subjects receiving implant surgery for missing dental elements. (controls)
Exclusion criteria
Exclusion criteria: Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Differences in histomorphometric parameters between healthy and irradiated human jaw bone and jaw bone involved in an osteoradionecrosis lesion. - Gene expression profiles of irradiated oral mucosa and oral mucosa associated with an osteoradionecrosis lesion compared to healthy oral mucosa. - Differences in cell surface characteristics (microplication and microvilli) of irradiated and non irradiated oral mucosa and oral mucosa associated with an osteoradionecrosis lesion. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Abnormalities in histomorphometric parameters in jaw bone of smokers in the control group and non-irradiated patients treated for a malignancy of the oral cavity compared to non-smoking controls. - Genexpressieprofiles in oral mucosa of smokers in the control group as opposed to non-smokers and gene expression profiles of non-irradiated patients treated for a malignancy of the oral cavity compared to non smoking controls. - Cell surface characteristics (microplications and microvilli) in the oral mucosa of smokers in the control group and in non-irradiated patienst treated for a malignancy of the oral cavity compared to non-smokers. These parameters are important to filter the contributing effect of smoking and malignancy to oral tissue alterations in irradiated oral cancer patients. | — |
Countries
Netherlands
Outcome results
None listed