brittle bone disease Osteogenesis imperfecta
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Wheelchair-bound patients with OI: * Boys and girls aged 8 to 25 years,will be enrolled; * Diagnosis of OI and using a wheelchair (for long distances); * Modified Bleck score
Exclusion criteria
Exclusion criteria: Wheelchair-bound patients with OI: * A medical status that contraindicates exercise (e.g. cardiomyopathy); * The use of medication affecting exercise capacity; * Unable to cooperate with the testing procedures (e.g. insufficient understanding of the Dutch language).;Healthy peers: * A medical status that contraindicates exercise; * The use of medication affecting exercise capacity; * Cardiovascular or respiratory disease; * Impaired motor development; * Morbid obesity (body mass index (BMI) >35 kg/m2); * Unable to cooperate with the testing procedures (e.g. insufficient understanding of the Dutch language).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reliability (test re-test reliability/reproducibility) of the shuttle ride test ; Validity of the shuttle ride test (attained peak heart rate and peak respiratory exchange ratio); Maximal oxygen consumption (VO2peak) attained during the shuttle ride test (health-related fitness); Rating of perceived exertion directly after the shuttle ride test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle force (grip strength and one-stroke push test); Fatigue (18-item PedsQL multidimensional fatigue scale); Activities in daily life (wearing an accelerometer for one week). | — |
Countries
Netherlands
Outcome results
None listed