n.a.
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: A patient must be over 18 years of age. A patient must have undergone a kidney transplantation and must be treated by nephrologists from the Renal Transplant Unit in the Academic Medical Centre. A patient must be eligible for a kidney biopsy in the context of standard clinical indications.
Exclusion criteria
Exclusion criteria: All patients who do not meet any of the inclusion criteria All patients who experience any serious adverse events will be excluded from further participation in this study All patients for whom it is regarded unsafe for any reason, by the treating transplant nephrologist, to undergo the interventions described in detail in the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T cell phenotypes Specificity of circulating and renal-residing T cells Function of kidney-resident T cells Cross-reactivity of kidney-resident T cells | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal biopsies contain renal tubular epithelial cells, which seem to play a role in shaping the immuneresponse against viruses. We will isolate renal tubular epithelial cells, after T cell isolation and use these cells to elucidate the role of renal epithelial cells in immunresponses against virusses and in allograft rejection. | — |
Countries
Netherlands
Outcome results
None listed