Non-invasive mapping of the Cerebrovascular Reactivity with ASL, BOLD and VASO MRI using different stimuli in young and elderly healthy volunteers

Non-invasive mapping of the Cerebrovascular Reactivity with ASL, BOLD and VASO MRI using different stimuli in young and elderly healthy volunteers - CVR measurements with MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39116

Enrollment

Registered

2010-12-14

Start date

2011-10-17

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microvascular pathologies of the brain Vascular diseases of the brain

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers (males of females) from the age groups of 18-35 years (25+15 (Addendum)) and 60-75 years (15 volunteers) 2. Volunteer participation 3. Having given their written informed consent 4. Willing to comply with the study procedures 5. Willing to accept use of all anonymized data, including publication, and confidential use and storage of all data

Exclusion criteria

Exclusion criteria: 1. Smoking or having stopped smoking shorter than 10 years ago 2. Having cardiovascular disease (inc. diabetes and hypertension) 3. Having brain disease 4. Using drugs 5. having metal implants 6. Claustrophobic or other mental and physical status that is incompatible with the proper study conduct 7. Not having a General Practitioner.

Design outcomes

Primary

Measure	Time frame
Cerebral Blood Flow (CBF=ml blood/100 ml brain tissue/minute), relative Cerebral Blood Volume (rCBV=ml blood/100 ml brain tissue) and Blood Oxygenation Level Dependent (BOLD=%). MCA diameter (mm)	—

Secondary

Measure	Time frame
None.	—

Countries

Netherlands

Outcome results