Ventriculo-arterial discordance
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: transposition of the great arteries arterial switch operation in WKZ 12 years of age or older wiritten informed consent
Exclusion criteria
Exclusion criteria: For MRI: pacemaker, claustrophobia, decreased renal function (the latter only for use of Gadolinium late enhancement)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The predictive value of several serum markers to assess poor left ventricular function in patients after ASO will be evaluated, with echocardiography and Magnetic Resonance Imaging (MRI) as reference. The predictive value of serum endothelial damage markers to determine presence of atherosclerosis will be assessed with Carotid Intima-Media Thickness (CIMT) and Computed Tomography (CT) scan as reference. Also, the serum endothelial markers will be correlated to endothelial dysfunction as established by flow mediated dilation (FMD). | — |
Primary
| Measure | Time frame |
|---|---|
| For the 1st objective, endpoints will be occurrence of an adverse outcome (e.g. late mortility, reoperation, diminished LV function, arrhythmia, signs of myocardial ischemia) and the operation related factors that are independently associated with these outcomes. For the 2nd objective, the extent and incidence of wall irregularities in the coronary arteries and the calcium score will be determined in ASO patients. To gain more insight in the pathophysiology behind this, both details of the anatomy of the coronary arteries, endothelial function and the presence of endothelial and immunological markers will be investigated. | — |
Countries
Netherlands
Outcome results
None listed