Affective disorder Depression
Conditions
Interventions
Patients: randomized treatment with a SSRI or CBT and 2 PET scans before and
after 8 weeks of treatment + 1 MRI
healthy controls: 1 PET scan + 1 MRI.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients - Out-patients - Age 18-55. - Major depressive disorder, single or recurrent episode according to DSM IV. - Severity: >22 IDS-SR - No psychotic features - No intention to commit suicide, or a history of a seroious suicide attempt - No proven non-response to CBT during the current or a previous episode - No current or recent (1 month) and no current (
Exclusion criteria
Exclusion criteria: Similar for patients and healthy controls - Indication of medical/somatic illness that could interfere with study results or constitutes a risk factor when participating in the study and undergoing treatment. - Cardiovascular abnormalities that may be a risk factor when participating in the study. - Neurological damage or previous severe head injury - Consumption of chocolate, caffeinated products or tabacco within 24 hours of the scan. - Pregnancy or the intention to become pregnant during the estimated time course of the study. - Radiation exposure (for diagnostic reasons) as a radiological worker or during medical trial in the previous year. - Claustrophobia - Presence of materials in the body that can be magnetized, like: i. A pacemaker ii. Metal fragments iii. Shunts iv. Artificial heart valves v. Vascular clips vi. Fixed hearing aid vii. Tattoos containing metal viii. Hair implants ix. Artificial dentures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter is the constant accumulation Kacc or Patlak rate (similar parameters resembling serotonin synthesis rate) in the brains, along with the scores on the IDS-SR. In addition, the k3, resembling AADC activity, will be measured. The difference (IDS-SR, Kacc, k3 or Patlak rate) between patients and healthy volunteers is shown as absolute values**. In addition, the Patlak Kacc and the scores on the IDS-SR correlated. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are the ratio between tryptophan levels in plasma and other large amino acids and polymorphisms for several serotonin-related genes like the serotonin transporter, the 5-HT1A receptor, and tryptophan hydroxylase. In addition, the outcomes of the personality questionnaires are compared between the two groups and aspects like neuroticism and copings style are correlated to Kacc and Patlak rates. Also the outcome of the fMRI tasks and the MRS are related to Kacc and Patlak rates. | — |
Countries
Netherlands
Outcome results
None listed