Tolerance of camels milk and mares milk in cow*s milk protein allergy.

Tolerance of camel*s milk and mare*s milk in cow*s milk protein allergy. - The PAKA study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39043

Enrollment

Registered

2012-02-20

Start date

2012-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

voedselallergiëen cow's milk allergy

Interventions

Participants are randomized to receive increasing doses of either camel*s milk or mare*s milk in a standardized provocation test. One to four weeks later the participants who first received camel*s

participants who did not show allergic reactions to both milks will be randomized to receive camel*s milk or mare*s milk daily during four weeks, and the other milk during the four weeks thereafter

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Cow's milk protein allergy proven by double-blind placebo-controlled provocation; >=3 years of age.

Exclusion criteria

Exclusion criteria: Experienced a life-threatening reaction to a food allergen; instable asthma.

Design outcomes

Primary

Measure	Time frame
Tolerance of camels and mares milk, as determined by provocation tests.	—

Secondary

Measure	Time frame
1. the minimum eliciting dose of camels milk and mares milk in CMA patients who do not tolerate these milk(s) in standardized food provocation tests; 2. medium-term (four weeks) tolerance of camels and/or mares milk in those participants who were negative in the provocation tests; 3. long-term (6-12 months) tolerance of camels and/or mares milk in those participants who were advised they could go on consuming the milk(s); 4. titer and affinity of specific IgE in serum to cows milk, camels milk and mares milk at the start of the study, and after four weeks of daily consumption of camels and/or mare*s milk; 5. the patients'experience with the consumption of camel's milk and mare's milk.	—

Measure

Time frame

1. the minimum eliciting dose of camel*s milk and mare*s milk in CMA patients who do not tolerate these milk(s) in standardized food provocation tests; 2. medium-term (four weeks) tolerance of camel*s and/or mare*s milk in those participants who were negative in the provocation tests; 3. long-term (6-12 months) tolerance of camel*s and/or mare*s milk in those participants who were advised they could go on consuming the milk(s); 4. titer and affinity of specific IgE in serum to cow*s milk, camel*s milk and mare*s milk at the start of the study, and after four weeks of daily consumption of camel*s and/or mare*s milk; 5. the patients'experience with the consumption of camel's milk and mare's milk.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)

Tolerance of camel*s milk and mare*s milk in cow*s milk protein allergy.