fat accumulation in liver and muscle Insulin resistance
Conditions
Interventions
Subjects will report to the university at 7.00 h, after a 9 hours (overnight)
fasting period. They will undergo a 1H-MRS scan to determine baseline IHL and
IMCL levels. Subsequently the subjects wil
Sponsors
Maastricht University
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18-65 years - Healthy - Stable dietary habits - No use of medication - Lean subjects: BMI 18-25 kg/m2 - Obese subjects: BMI 30-35 kg/m2
Exclusion criteria
Exclusion criteria: - Any medical condition requiring treatment and/or medication use - Alcohol consumption of more than 20 g per day (± 2 units) - Smoking - Unstable body weight (weight gain or loss > 3 kg in the past three months) - Participation in another biomedical study within 1 month prior to the screening visit - Contraindications for MRI scan (cochlear implant, pacemaker, claustrophobia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change of IHL and IMCL concentrations in the late postprandial phase, compared to baseline measurement after an overnight fast. | — |
Secondary
| Measure | Time frame |
|---|---|
| We also aim to investigate whether the addition of protein to a high fat breakfast (HFP) results in a reduced postprandial accumulation of lipids when compared to a high fat breakfast (HF) alone. | — |
Countries
Netherlands
Outcome results
None listed