letsel van de milt na trauma Splenic trauma
Conditions
Interventions
Vaccination
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Adult patients (*18 years old) * Treated with embolisation for splenic injury after trauma , * 6 months ago * Master the Dutch, English or French language and fully able to understand the information provided * Voluntarily written informed consent
Exclusion criteria
Exclusion criteria: * Limited mental capacity or language skills such that explanations and instructions (regarding adverse events) cannot be followed * Patients with splenic injury treated with observational management or splenic surgery (laparotomy with splenectomy or splenorrhaphy) * Patients treated with a combination of proximal and distal embolisation * Patients who have received a pneumococcal vaccine in the past 5 years * Blood donation or blood loss greater than 400 ml in the last 3 months * Participation in (an)other medical study(ies) * Allergies for previously administered vaccines * Patients with acute or chronic illness that may affect immunity * Patients with comorbidity affecting splenic function (i.e. haematological or immunological diseases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Immunological: the antibody response to polysaccharide antigens, before and after administration of the Pneumo-23® vaccine, and 2. haematological: the presence and quantification of Howell-Jolly Bodies in peripheral blood. | — |
Countries
Netherlands
Outcome results
None listed