HCHWA-D a monogenetic model for intracerebral hemorrhage

HCHWA-D a monogenetic model for intracerebral hemorrhage - HCHWA-D a monogenetic model for intracerebral hemorrhage

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38982

Enrollment

Registered

2013-09-04

Start date

2013-09-05

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

familial amyloid angiopathy HCHWA-D

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: HCHWA-D patients 1. Age * 18y 2. Written informed consent from the patient or in case the patients is not able to give informed consent from his/her legal representative (see appendix 2 for the evaluation of the (mental) ability of the patient to give informed consent). 3. Presence of the amyloid precursor protein codon 693 mutation or a hemorrhage pattern on CT or MRI suspect for amyloid angiopathy and first degree relative with HCHWA-D. sCAA patients 1. Age * 18y 2. Written informed consent from the patient or in case the patients is not able to give informed consent from his/her legal representative (see appendix 2 for the evaluation of the (mental) ability of the patient to give informed consent). 3. Probable CAA based on the modified Boston criteria and no family history of HCHWA-D (see appendix 1) 15 In case there is doubt about a possible familiar type of sCAA a DNA test will be offered to the patients to test for HCHWA-D.

Exclusion criteria

Exclusion criteria: * Age

Design outcomes

Primary

Measure	Time frame
There are several primary study parameters. The main parameters are triggers of ICH, presence of the spot sign on CT, hematoma progression on CT, amyloid and microvascular changes on 3T/7T MRI, recurrence rate and clinical outcome.	—

Countries

Netherlands

Outcome results