decompensatio cordis heart decompensation heart failure
Conditions
Interventions
For the second aim, we will administer dietary nitrate through beetroot juice.
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: - Patients diagnosed with heart failure NYHA class II/III - >= 18 years of age - Mentally able/allowed to give informed consent;Controls: - Subjects free of cardiovascular disease and/or cardiovascular medication - >= 18 years of age - Mentally able/allowed to give informed consent
Exclusion criteria
Exclusion criteria: Controls: Cardiovascular disease The use of cardiovascular medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| magnitude of decline in the combined oxygenated hemoglobin (HbO2) and myoglobin (MbO2) signal from the near-infrared spectroscopy during the cold pressor test at rest and during handgrip exercise at 10 and 30% MVC combined with the cold pressor test. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Brachial artery blood flow (using non-invasive ultrasound as a secondary measure of exercise-induced blood flow during handgrip and performance of the cold pressor test) - Mean arterial blood pressure (Nexfin, contra-lateral arm) (to control for potential differences in the blood pressure response between the subsequent tests) - Forearm blood flow using plethysmography (contra-lateral arm) | — |
Countries
Netherlands
Outcome results
None listed